Assay Detail
Functional
CHEMBL1914033
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human M21 cells after 48 hrs by SRB assay
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | M21 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonamides as antimitotics. Antiproliferative, antiangiogenic and antitumoral activity, and quantitative structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 6.88 | 8.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.37 |
| CHEMBL1911770 | — | — | 1 | 7.89 |
| CHEMBL1911763 | — | — | 1 | 7.60 |
| CHEMBL1911757 | — | — | 1 | 7.57 |
| CHEMBL1911762 | — | — | 1 | 7.23 |
| CHEMBL1911769 | — | — | 1 | 7.22 |
| CHEMBL1911765 | — | — | 1 | 7.20 |
| CHEMBL1911760 | — | — | 1 | 7.19 |
| CHEMBL1911758 | — | — | 1 | 7.16 |
| CHEMBL1911759 | — | — | 1 | 7.09 |
| CHEMBL1911761 | — | — | 1 | 7.08 |
| CHEMBL1911791 | — | — | 1 | 7.06 |
| CHEMBL1911783 | — | — | 1 | 7.05 |
| CHEMBL1911764 | — | — | 1 | 7.03 |
| CHEMBL1911755 | — | — | 1 | 6.96 |
| CHEMBL1911790 | — | — | 1 | 6.89 |
| CHEMBL1911782 | — | — | 1 | 6.89 |
| CHEMBL1911752 | — | — | 1 | 6.82 |
| CHEMBL1911756 | — | — | 1 | 6.82 |
| CHEMBL1911753 | — | — | 1 | 6.75 |
| CHEMBL1911788 | — | — | 1 | 6.72 |
| CHEMBL1911751 | — | — | 1 | 6.70 |
| CHEMBL1911767 | — | — | 1 | 6.66 |
| CHEMBL1911784 | — | — | 1 | 6.64 |
| CHEMBL1911771 | — | — | 1 | 6.58 |
| CHEMBL1911785 | — | — | 1 | 6.58 |
| CHEMBL1911754 | — | — | 1 | 6.52 |
| CHEMBL1911768 | — | — | 1 | 6.47 |
| CHEMBL1911789 | — | — | 1 | 6.43 |
| CHEMBL1911787 | — | — | 1 | 6.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL1911770 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1911763 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1911757 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL1911762 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL1911769 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1911765 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL1911760 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL1911758 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL1911759 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL1911761 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL1911791 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL1911783 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL1911764 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL1911755 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1911790 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1911782 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1911752 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1911756 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1911753 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1911788 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1911751 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1911767 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1911784 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL1911771 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1911785 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1911754 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1911768 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL1911789 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL1911787 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL1911773 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL1911772 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL1911780 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL1911779 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL1911776 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL1911766 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1911774 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1911775 | — | IC50 | > | 1001.0 | nM | - |
| CHEMBL1911777 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1911778 | — | IC50 | > | 1001.0 | nM | - |
| CHEMBL1911781 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1911786 | — | IC50 | > | 1000.0 | nM | - |