Assay Detail
Functional
CHEMBL1914072
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Antiproliferative activity against human K562 after 48 hrs by SRB assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonamides as antimitotics. Antiproliferative, antiangiogenic and antitumoral activity, and quantitative structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.40 | 9.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 9.44 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 9.15 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 8.17 |
| CHEMBL1911770 | — | — | 1 | 7.72 |
| CHEMBL1911763 | — | — | 1 | 7.16 |
| CHEMBL1911757 | — | — | 1 | 7.14 |
| CHEMBL1911762 | — | — | 1 | 7.06 |
| CHEMBL1911765 | — | — | 1 | 6.96 |
| CHEMBL1911769 | — | — | 1 | 6.96 |
| CHEMBL1911758 | — | — | 1 | 6.70 |
| CHEMBL1911759 | — | — | 1 | 6.64 |
| CHEMBL1911760 | — | — | 1 | 6.64 |
| CHEMBL1911791 | — | — | 1 | 6.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 0.71 | nM | 9.15 |
| CHEMBL107 | COLCHICINE | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL1911770 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1911763 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL1911757 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL1911762 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL1911765 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1911769 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1911758 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1911759 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL1911760 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL1911791 | — | IC50 | = | 340.0 | nM | 6.47 |