Assay Detail
Functional
CHEMBL1914079
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Antiproliferative activity against human SKOV3 after 48 hrs by SRB assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-OV-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonamides as antimitotics. Antiproliferative, antiangiogenic and antitumoral activity, and quantitative structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.42 | 10.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 10.41 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 8.68 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.59 |
| CHEMBL1911770 | — | — | 1 | 7.66 |
| CHEMBL1911763 | — | — | 1 | 7.16 |
| CHEMBL1911757 | — | — | 1 | 7.14 |
| CHEMBL1911762 | — | — | 1 | 6.77 |
| CHEMBL1911769 | — | — | 1 | 6.77 |
| CHEMBL1911765 | — | — | 1 | 6.72 |
| CHEMBL1911758 | — | — | 1 | 6.70 |
| CHEMBL1911759 | — | — | 1 | 6.64 |
| CHEMBL1911760 | — | — | 1 | 6.62 |
| CHEMBL1911791 | — | — | 1 | 6.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | IC50 | = | 0.039 | nM | 10.41 |
| CHEMBL107 | COLCHICINE | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL1911770 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1911763 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1911757 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL1911762 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1911769 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1911765 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1911758 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1911759 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL1911760 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL1911791 | — | IC50 | = | 280.0 | nM | 6.55 |