Assay Detail
Binding
CHEMBL1917973
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human 5-LOX in human PBML assessed as inhibition of A23187-induced LTB4 production preincubated for 15 mins measured after 15 mins by enzyme immunoassay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and biological evaluation of benzo[1.3.2]dithiazolium ylide 1,1-dioxide derivatives as potential dual cyclooxygenase-2/5-lipoxygenase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.82 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | — | 1 | 7.60 |
| CHEMBL1917102 | — | — | 1 | 6.82 |
| CHEMBL1917097 | — | — | 1 | 6.75 |
| CHEMBL1917099 | — | — | 1 | 6.52 |
| CHEMBL1917100 | — | — | 1 | 6.46 |
| CHEMBL1917098 | — | — | 1 | 6.44 |
| CHEMBL1917101 | — | — | 1 | 6.17 |
| CHEMBL1917103 | — | — | 1 | 5.51 |
| CHEMBL1917086 | — | — | 1 | 5.46 |
| CHEMBL1917105 | — | — | 1 | 5.43 |
| CHEMBL1917092 | — | — | 1 | 5.39 |
| CHEMBL1917090 | — | — | 1 | 5.22 |
| CHEMBL1917088 | — | — | 1 | 4.87 |
| CHEMBL1917087 | — | — | 1 | 4.59 |
| CHEMBL1917107 | — | — | 1 | 4.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1917102 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1917097 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1917099 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1917100 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL1917098 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL1917101 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL1917103 | — | IC50 | = | 3090.0 | nM | 5.51 |
| CHEMBL1917086 | — | IC50 | = | 3450.0 | nM | 5.46 |
| CHEMBL1917105 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL1917092 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL1917090 | — | IC50 | = | 6050.0 | nM | 5.22 |
| CHEMBL1917088 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL1917087 | — | IC50 | = | 25800.0 | nM | 4.59 |
| CHEMBL1917107 | — | IC50 | = | 91100.0 | nM | 4.04 |