Assay Detail
Binding
CHEMBL1918309
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Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
31
Total Activities
30
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | IM-9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, structure-activity relationship, and highly efficient asymmetric synthesis of 3-phenyl-4-benzylaminopiperidine derivatives as novel neurokinin-1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 9.83 | 10.92 |
| Ki | 1 | 10.60 | 10.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3215877 | — | — | 1 | 10.92 |
| CHEMBL1917864 | — | — | 2 | 10.77 |
| CHEMBL1917866 | — | — | 1 | 10.60 |
| CHEMBL557983 | VOFOPITANT DIHYDROCHLORIDE | -1.0 | 1 | 10.60 |
| CHEMBL1917853 | — | — | 1 | 10.41 |
| CHEMBL1917856 | — | — | 1 | 10.36 |
| CHEMBL1917852 | — | — | 1 | 10.31 |
| CHEMBL1917865 | — | — | 1 | 10.27 |
| CHEMBL1917851 | — | — | 1 | 10.27 |
| CHEMBL1917859 | — | — | 1 | 10.25 |
| CHEMBL1917862 | — | — | 1 | 10.24 |
| CHEMBL1917860 | — | — | 1 | 10.24 |
| CHEMBL1917850 | — | — | 1 | 10.12 |
| CHEMBL1917858 | — | — | 1 | 10.09 |
| CHEMBL1917867 | — | — | 1 | 10.08 |
| CHEMBL1917855 | — | — | 1 | 10.07 |
| CHEMBL1917857 | — | — | 1 | 10.03 |
| CHEMBL1917863 | — | — | 1 | 10.00 |
| CHEMBL1917861 | — | — | 1 | 9.89 |
| CHEMBL1917844 | — | — | 1 | 9.80 |
| CHEMBL1917845 | — | — | 1 | 9.77 |
| CHEMBL1917869 | — | — | 1 | 9.70 |
| CHEMBL1917843 | — | — | 1 | 9.51 |
| CHEMBL1917842 | — | — | 1 | 8.92 |
| CHEMBL3216988 | — | — | 1 | 8.85 |
| CHEMBL1917849 | — | — | 1 | 8.72 |
| CHEMBL1917846 | — | — | 1 | 8.43 |
| CHEMBL1917841 | — | — | 1 | 8.32 |
| CHEMBL3217199 | — | — | 1 | 8.08 |
| CHEMBL1917868 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3215877 | — | IC50 | = | 0.012 | nM | 10.92 |
| CHEMBL1917864 | — | IC50 | = | 0.017 | nM | 10.77 |
| CHEMBL557983 | VOFOPITANT DIHYDROCHLORIDE | Ki | = | 0.02512 | nM | 10.60 |
| CHEMBL1917866 | — | IC50 | = | 0.025 | nM | 10.60 |
| CHEMBL1917853 | — | IC50 | = | 0.039 | nM | 10.41 |
| CHEMBL1917856 | — | IC50 | = | 0.044 | nM | 10.36 |
| CHEMBL1917852 | — | IC50 | = | 0.049 | nM | 10.31 |
| CHEMBL1917865 | — | IC50 | = | 0.054 | nM | 10.27 |
| CHEMBL1917851 | — | IC50 | = | 0.054 | nM | 10.27 |
| CHEMBL1917859 | — | IC50 | = | 0.056 | nM | 10.25 |
| CHEMBL1917860 | — | IC50 | = | 0.057 | nM | 10.24 |
| CHEMBL1917862 | — | IC50 | = | 0.057 | nM | 10.24 |
| CHEMBL1917864 | — | IC50 | = | 0.073 | nM | 10.14 |
| CHEMBL1917850 | — | IC50 | = | 0.075 | nM | 10.12 |
| CHEMBL1917858 | — | IC50 | = | 0.081 | nM | 10.09 |
| CHEMBL1917867 | — | IC50 | = | 0.084 | nM | 10.08 |
| CHEMBL1917855 | — | IC50 | = | 0.086 | nM | 10.07 |
| CHEMBL1917857 | — | IC50 | = | 0.093 | nM | 10.03 |
| CHEMBL1917863 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL1917861 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL1917844 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL1917845 | — | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL1917869 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL1917843 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL1917842 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL3216988 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL1917849 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL1917846 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL1917841 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL3217199 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL1917868 | — | IC50 | > | 100.0 | nM | - |