Assay Detail
Binding
CHEMBL1918322
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV1 integrase strand transfer by biochemical assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Combining symmetry elements results in potent naphthyridinone (NTD) HIV-1 integrase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.91 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1917873 | — | — | 1 | 9.00 |
| CHEMBL1914460 | — | — | 1 | 8.40 |
| CHEMBL1917874 | — | — | 1 | 8.22 |
| CHEMBL1917876 | — | — | 1 | 8.22 |
| CHEMBL1914553 | — | — | 1 | 8.22 |
| CHEMBL1914551 | — | — | 1 | 8.15 |
| CHEMBL1914564 | — | — | 1 | 8.10 |
| CHEMBL1914554 | — | — | 1 | 8.10 |
| CHEMBL1914552 | — | — | 1 | 8.00 |
| CHEMBL1917875 | — | — | 1 | 7.89 |
| CHEMBL1917872 | — | — | 1 | 7.89 |
| CHEMBL1914562 | — | — | 1 | 7.85 |
| CHEMBL1914556 | — | — | 1 | 7.77 |
| CHEMBL1914557 | — | — | 1 | 7.75 |
| CHEMBL1914563 | — | — | 1 | 7.72 |
| CHEMBL1914555 | — | — | 1 | 7.70 |
| CHEMBL1914559 | — | — | 1 | 7.55 |
| CHEMBL1914560 | — | — | 1 | 7.55 |
| CHEMBL1914550 | — | — | 1 | 7.50 |
| CHEMBL1914561 | — | — | 1 | 7.50 |
| CHEMBL1914558 | — | — | 1 | 7.47 |
| CHEMBL1917877 | — | — | 1 | 7.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1917873 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1914460 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1917874 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1917876 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1914553 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1914551 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1914564 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1914554 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1914552 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1917875 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1917872 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1914562 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1914556 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1914557 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1914563 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1914555 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1914559 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL1914560 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL1914550 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL1914561 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL1914558 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL1917877 | — | IC50 | = | 35.0 | nM | 7.46 |