Assay Detail
Functional
CHEMBL1918441
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MCF7 cells after 72 hrs by SRB assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of callophycin A and analogues as potential chemopreventive and anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.79 | 7.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.25 |
| CHEMBL1915174 | — | — | 1 | 4.83 |
| CHEMBL1915173 | — | — | 1 | 4.74 |
| CHEMBL1915155 | — | — | 1 | 4.66 |
| CHEMBL1915168 | — | — | 1 | 4.59 |
| CHEMBL1915172 | — | — | 1 | 4.56 |
| CHEMBL1915169 | — | — | 1 | 4.45 |
| CHEMBL1915156 | — | — | 1 | 4.43 |
| CHEMBL1915170 | — | — | 1 | 4.43 |
| CHEMBL1915166 | — | — | 1 | 4.42 |
| CHEMBL1915157 | — | — | 1 | 4.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL1915174 | — | IC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL1915173 | — | IC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL1915155 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL1915168 | — | IC50 | = | 25400.0 | nM | 4.59 |
| CHEMBL1915172 | — | IC50 | = | 27700.0 | nM | 4.56 |
| CHEMBL1915169 | — | IC50 | = | 35800.0 | nM | 4.45 |
| CHEMBL1915156 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL1915170 | — | IC50 | = | 36900.0 | nM | 4.43 |
| CHEMBL1915166 | — | IC50 | = | 38400.0 | nM | 4.42 |
| CHEMBL1915157 | — | IC50 | = | 42100.0 | nM | 4.38 |