Assay Detail
Binding
CHEMBL1918703
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of soluble guanylate cyclase in Sprague-Dawley rat thoracic aorta rings assessed as inhibition of phenylepherine-evoked vasoconstriction in presence of nitric oxide donor, DETA-NO
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Thoracic aorta |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Acidic triazoles as soluble guanylate cyclase stimulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.52 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1916024 | — | — | 1 | 7.96 |
| CHEMBL1916039 | — | — | 1 | 7.48 |
| CHEMBL1916027 | — | — | 1 | 7.40 |
| CHEMBL1916036 | — | — | 1 | 7.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1916024 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1916039 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL1916027 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1916036 | — | IC50 | = | 60.0 | nM | 7.22 |