Assay Detail
Binding
CHEMBL1918965
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Inhibition of recombinant human PDE7A using [3H]cAMP after 1 hr by scintillation proximity assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A (CHEMBL3012) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Highly potent, selective, and orally active phosphodiesterase 10A inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.98 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1915906 | — | — | 1 | 6.58 |
| CHEMBL1915891 | — | — | 1 | 6.48 |
| CHEMBL1915888 | — | — | 1 | 6.27 |
| CHEMBL1915912 | — | — | 1 | 6.08 |
| CHEMBL1916106 | — | — | 1 | 6.04 |
| CHEMBL1915910 | — | — | 1 | 5.93 |
| CHEMBL1915892 | — | — | 1 | 5.89 |
| CHEMBL1916108 | — | — | 1 | 5.87 |
| CHEMBL1916091 | — | — | 1 | 5.63 |
| CHEMBL1915896 | — | — | 1 | 5.53 |
| CHEMBL1086110 | — | — | 1 | 5.48 |
| CHEMBL1916113 | — | — | 1 | - |
| CHEMBL1916114 | — | — | 1 | - |
| CHEMBL1916123 | — | — | 1 | - |
| CHEMBL1916124 | — | — | 1 | - |
| CHEMBL1916125 | — | — | 1 | - |
| CHEMBL1916130 | — | — | 1 | - |
| CHEMBL1916131 | — | — | 1 | - |
| CHEMBL1916132 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1915906 | — | IC50 | = | 266.0 | nM | 6.58 |
| CHEMBL1915891 | — | IC50 | = | 332.0 | nM | 6.48 |
| CHEMBL1915888 | — | IC50 | = | 542.0 | nM | 6.27 |
| CHEMBL1915912 | — | IC50 | = | 824.0 | nM | 6.08 |
| CHEMBL1916106 | — | IC50 | = | 919.0 | nM | 6.04 |
| CHEMBL1915910 | — | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL1915892 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1916108 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL1916091 | — | IC50 | = | 2318.0 | nM | 5.63 |
| CHEMBL1915896 | — | IC50 | = | 2930.0 | nM | 5.53 |
| CHEMBL1086110 | — | IC50 | = | 3345.0 | nM | 5.48 |
| CHEMBL1916113 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1916114 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1916123 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1916124 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1916125 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1916130 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL1916131 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1916132 | — | IC50 | > | 1000.0 | nM | - |