Assay Detail
Functional
CHEMBL1920056
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Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and apoptosis inducing ability of new anilino substituted pyrimidine sulfonamides as potential anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.08 | 6.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1642 | IMATINIB MESYLATE | 4.0 | 1 | 6.08 |
| CHEMBL1916725 | — | — | 1 | 5.03 |
| CHEMBL1916724 | — | — | 1 | 5.00 |
| CHEMBL1916727 | — | — | 1 | 4.94 |
| CHEMBL1916728 | — | — | 1 | 4.94 |
| CHEMBL1916721 | — | — | 1 | 4.93 |
| CHEMBL1916722 | — | — | 1 | 4.93 |
| CHEMBL1916723 | — | — | 1 | 4.92 |
| CHEMBL1916726 | — | — | 1 | 4.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1642 | IMATINIB MESYLATE | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL1916725 | — | IC50 | = | 9330.0 | nM | 5.03 |
| CHEMBL1916724 | — | IC50 | = | 9960.0 | nM | 5.00 |
| CHEMBL1916727 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL1916728 | — | IC50 | = | 11560.0 | nM | 4.94 |
| CHEMBL1916721 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL1916722 | — | IC50 | = | 11860.0 | nM | 4.93 |
| CHEMBL1916723 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL1916726 | — | IC50 | = | 12300.0 | nM | 4.91 |