Assay Detail
ADMET
CHEMBL1920272
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Cytotoxicity against pig LLC-PK1 cells transfected with empty vector after 72 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Sus scrofa |
| Cell Type | LLC-PK1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity evaluation of isatin-β-thiosemicarbazones with improved selective activity toward multidrug-resistant cells expressing P-glycoprotein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.05 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.70 |
| CHEMBL1915697 | — | — | 1 | 4.55 |
| CHEMBL1915706 | — | — | 1 | 4.53 |
| CHEMBL504574 | — | — | 1 | 4.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1915697 | — | IC50 | = | 28380.0 | nM | 4.55 |
| CHEMBL1915706 | — | IC50 | = | 29310.0 | nM | 4.53 |
| CHEMBL504574 | — | IC50 | = | 36790.0 | nM | 4.43 |