Assay Detail
Functional
CHEMBL1920390
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Agonist activity at human S1P1 receptor
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and characterization of potent and selective 4-oxo-4-(5-(5-phenyl-1,2,4-oxadiazol-3-yl)indolin-1-yl)butanoic acids as S1P₁ agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.54 | 8.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1916400 | — | — | 1 | 8.17 |
| CHEMBL1916402 | — | — | 1 | 8.03 |
| CHEMBL1916401 | — | — | 1 | 6.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1916400 | — | EC50 | = | 6.7 | nM | 8.17 |
| CHEMBL1916402 | — | EC50 | = | 9.4 | nM | 8.03 |
| CHEMBL1916401 | — | EC50 | = | 372.0 | nM | 6.43 |