Assay Detail
Functional
CHEMBL1920392
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human S1P1 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production after 1 hr by HTRF assay
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and characterization of potent and selective 4-oxo-4-(5-(5-phenyl-1,2,4-oxadiazol-3-yl)indolin-1-yl)butanoic acids as S1P₁ agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 39 | 8.01 | 9.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1916564 | — | — | 1 | 9.09 |
| CHEMBL1916570 | — | — | 1 | 9.00 |
| CHEMBL1916409 | — | — | 1 | 9.00 |
| CHEMBL1916569 | — | — | 1 | 8.96 |
| CHEMBL1916399 | — | — | 1 | 8.92 |
| CHEMBL1916558 | — | — | 1 | 8.92 |
| CHEMBL1916565 | — | — | 1 | 8.89 |
| CHEMBL1916568 | — | — | 1 | 8.82 |
| CHEMBL1916563 | — | — | 1 | 8.79 |
| CHEMBL1916572 | — | — | 1 | 8.57 |
| CHEMBL1916571 | — | — | 1 | 8.40 |
| CHEMBL1916405 | — | — | 1 | 8.38 |
| CHEMBL1916553 | — | — | 1 | 8.37 |
| CHEMBL1916559 | — | — | 1 | 8.34 |
| CHEMBL1916404 | — | — | 1 | 8.31 |
| CHEMBL1916573 | — | — | 1 | 8.28 |
| CHEMBL1916560 | — | — | 1 | 8.21 |
| CHEMBL1916574 | — | — | 1 | 8.20 |
| CHEMBL1916561 | — | — | 1 | 8.18 |
| CHEMBL1916402 | — | — | 1 | 8.14 |
| CHEMBL1916403 | — | — | 1 | 8.01 |
| CHEMBL1916580 | — | — | 1 | 7.99 |
| CHEMBL1916577 | — | — | 1 | 7.96 |
| CHEMBL1916575 | — | — | 1 | 7.96 |
| CHEMBL1916576 | — | — | 1 | 7.75 |
| CHEMBL1916566 | — | — | 1 | 7.75 |
| CHEMBL1916410 | — | — | 1 | 7.62 |
| CHEMBL1916554 | — | — | 1 | 7.43 |
| CHEMBL1916578 | — | — | 1 | 7.42 |
| CHEMBL1916557 | — | — | 1 | 7.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1916564 | — | EC50 | = | 0.82 | nM | 9.09 |
| CHEMBL1916570 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1916409 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1916569 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL1916399 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL1916558 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL1916565 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL1916568 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL1916563 | — | EC50 | = | 1.63 | nM | 8.79 |
| CHEMBL1916572 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL1916571 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1916405 | — | EC50 | = | 4.2 | nM | 8.38 |
| CHEMBL1916553 | — | EC50 | = | 4.3 | nM | 8.37 |
| CHEMBL1916559 | — | EC50 | = | 4.6 | nM | 8.34 |
| CHEMBL1916404 | — | EC50 | = | 4.9 | nM | 8.31 |
| CHEMBL1916573 | — | EC50 | = | 5.3 | nM | 8.28 |
| CHEMBL1916560 | — | EC50 | = | 6.1 | nM | 8.21 |
| CHEMBL1916574 | — | EC50 | = | 6.3 | nM | 8.20 |
| CHEMBL1916561 | — | EC50 | = | 6.6 | nM | 8.18 |
| CHEMBL1916402 | — | EC50 | = | 7.2 | nM | 8.14 |
| CHEMBL1916403 | — | EC50 | = | 9.8 | nM | 8.01 |
| CHEMBL1916580 | — | EC50 | = | 10.3 | nM | 7.99 |
| CHEMBL1916577 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1916575 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1916576 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1916566 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1916410 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1916554 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL1916578 | — | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL1916557 | — | EC50 | = | 41.0 | nM | 7.39 |
| CHEMBL1916567 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL1916555 | — | EC50 | = | 54.0 | nM | 7.27 |
| CHEMBL1916579 | — | EC50 | = | 68.0 | nM | 7.17 |
| CHEMBL1916411 | — | EC50 | = | 75.0 | nM | 7.12 |
| CHEMBL1916562 | — | EC50 | = | 102.0 | nM | 6.99 |
| CHEMBL1916407 | — | EC50 | = | 297.0 | nM | 6.53 |
| CHEMBL1916556 | — | EC50 | = | 369.0 | nM | 6.43 |
| CHEMBL1916408 | — | EC50 | = | 406.0 | nM | 6.39 |
| CHEMBL1916406 | — | EC50 | > | 100.0 | nM | - |