Assay Detail
Functional
CHEMBL1920606
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Antimalarial activity against chloroquine- and mefloquine-resistant Plasmodium falciparum W2-Mef infected in human O-positive erythrocytes assessed as inhibition of schizonts growth after 48 hrs
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
3-bromohomofascaplysin A, a fascaplysin analogue from a Fijian Didemnum sp. ascidian.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.13 | 8.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 8.23 |
| CHEMBL258765 | FASCAPLYSIN CHLORIDE | — | 1 | 7.19 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.10 |
| CHEMBL1915273 | HOMOFASCAPLYSINE A | — | 1 | 7.03 |
| CHEMBL1915272 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | IC50 | = | 5.91 | nM | 8.23 |
| CHEMBL258765 | FASCAPLYSIN CHLORIDE | IC50 | = | 65.2 | nM | 7.19 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1915273 | HOMOFASCAPLYSINE A | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL1915272 | — | IC50 | = | 765.0 | nM | 6.12 |