Assay Detail
Functional
CHEMBL1920681
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human NCI-H441 cells after 72 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H441 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Activation of the c-Jun N-terminal kinase/activating transcription factor 3 (ATF3) pathway characterizes effective arylated diazeniumdiolate-based nitric oxide-releasing anticancer prodrugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.75 | 6.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL455983 | — | — | 1 | 6.03 |
| CHEMBL212378 | — | — | 1 | 5.85 |
| CHEMBL1917522 | — | — | 1 | 5.79 |
| CHEMBL1917523 | — | — | 1 | 5.70 |
| CHEMBL1917524 | — | — | 1 | 5.60 |
| CHEMBL1917525 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL455983 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL212378 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL1917522 | — | IC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL1917523 | — | IC50 | = | 2020.0 | nM | 5.70 |
| CHEMBL1917524 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1917525 | — | IC50 | = | 3150.0 | nM | 5.50 |