Assay Detail
Binding
CHEMBL1920950
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Inhibition of human recombinant MAOA expressed in baculovirus infected BTI-TN-5B1-4 insect cells assessed as hydrogen peroxide production from p-tyramine after 15 mins by amplex red assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BTI-TN-5B1-4 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
2D MI-DRAGON: a new predictor for protein-ligands interactions and theoretic-experimental studies of US FDA drug-target network, oxoisoaporphine inhibitors for MAO-A and human parasite proteins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.51 | 9.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1651055 | — | — | 1 | 9.08 |
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | 8.40 |
| CHEMBL1917530 | — | — | 1 | 7.89 |
| CHEMBL1651054 | — | — | 1 | 7.85 |
| CHEMBL1917529 | — | — | 1 | 7.46 |
| CHEMBL1917527 | — | — | 1 | 7.36 |
| CHEMBL461133 | — | — | 1 | 6.14 |
| CHEMBL1917528 | — | — | 1 | 5.91 |
| CHEMBL1917531 | — | — | 1 | 5.67 |
| CHEMBL92401 | IPRONIAZID | 2.0 | 1 | 5.18 |
| CHEMBL1917532 | — | — | 1 | 5.01 |
| CHEMBL1917526 | — | — | 1 | 4.56 |
| CHEMBL972 | SELEGILINE | 4.0 | 1 | 4.16 |
| CHEMBL86304 | MOCLOBEMIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1651055 | — | IC50 | = | 0.83 | nM | 9.08 |
| CHEMBL8706 | CLORGILINE | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1917530 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1651054 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1917529 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL1917527 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL461133 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL1917528 | — | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL1917531 | — | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL92401 | IPRONIAZID | IC50 | = | 6560.0 | nM | 5.18 |
| CHEMBL1917532 | — | IC50 | = | 9810.0 | nM | 5.01 |
| CHEMBL1917526 | — | IC50 | = | 27320.0 | nM | 4.56 |
| CHEMBL972 | SELEGILINE | IC50 | = | 68730.0 | nM | 4.16 |
| CHEMBL86304 | MOCLOBEMIDE | IC50 | = | 361380.0 | nM | - |