Assay Detail

CHEMBL1921048

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Functional

Antagonist activity at AR

ChEMBL ↗

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Target

Aldo-keto reductase family 1 member B1 (CHEMBL1900) ↗

Open DB target context

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Aldo-keto reductase family 1 member B1 (CHEMBL1900) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Aldo-keto reductase family 1 member B1

CHEMBL1900

Anchored from Assay target.

Protein identity Aldo-keto reductase family 1 member B1

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Confidence	8 — Homologous single protein target
Curated By	Autocuration

Target

Aldo-keto reductase family 1 member B1 (CHEMBL1900) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Discovery of potent, selective, and orally bioavailable alkynylphenoxyacetic acid CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases.

Crosignani S, Prêtre A, Jorand-Lebrun C, Fraboulet G, Seenisamy J, Augustine JK, Missotten M, Humbert Y, Cleva C, Abla N, Daff H, Schott O, Schneider M, Burgat-Charvillon F, Rivron D, Hamernig I, Arrighi JF, Gaudet M, Zimmerli SC, Juillard P, Johnson Z.
J Med Chem (2011) 54 : 7299 -7317
PubMed 21916510 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.76	6.76

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1917584	—	—	1	6.76

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1917584	—	IC50	=	172.0	nM	6.76