Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1921080

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of HIV1 gp41 assessed as gp41-six-helix bundle formation after 30 mins by sandwich ELISA
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Human immunodeficiency virus 1
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Design, synthesis and biological evaluation of 3-substituted 2,5-dimethyl-N-(3-(1H-tetrazol-5-yl)phenyl)pyrroles as novel potential HIV-1 gp41 inhibitors.
He XY, Zou P, Qiu J, Hou L, Jiang S, Liu S, Xie L.
Bioorg Med Chem (2011) 19 : 6726 -6734
PubMed 22014749 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 4.96 5.57

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1917731 1 5.57
CHEMBL1917571 1 5.51
CHEMBL1917730 1 5.50
CHEMBL1917570 1 5.36
CHEMBL1917733 1 5.34
CHEMBL1917573 1 5.11
CHEMBL1914492 1 5.04
CHEMBL1917569 1 4.92
CHEMBL1917734 1 4.90
CHEMBL1917732 1 4.69
CHEMBL1917736 1 4.65
CHEMBL526168 1 4.59
CHEMBL1917735 1 4.55
CHEMBL1917737 1 4.38
CHEMBL405828 1 4.23
CHEMBL1917574 1 -
CHEMBL1917572 1 -
CHEMBL1917568 1 -
CHEMBL1917567 1 -
CHEMBL1917566 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1917731 IC50 = 2700.0 nM 5.57
CHEMBL1917571 IC50 = 3100.0 nM 5.51
CHEMBL1917730 IC50 = 3200.0 nM 5.50
CHEMBL1917570 IC50 = 4400.0 nM 5.36
CHEMBL1917733 IC50 = 4600.0 nM 5.34
CHEMBL1917573 IC50 = 7700.0 nM 5.11
CHEMBL1914492 IC50 = 9200.0 nM 5.04
CHEMBL1917569 IC50 = 12100.0 nM 4.92
CHEMBL1917734 IC50 = 12700.0 nM 4.90
CHEMBL1917732 IC50 = 20600.0 nM 4.69
CHEMBL1917736 IC50 = 22600.0 nM 4.65
CHEMBL526168 IC50 = 25600.0 nM 4.59
CHEMBL1917735 IC50 = 28100.0 nM 4.55
CHEMBL1917737 IC50 = 41600.0 nM 4.38
CHEMBL405828 IC50 = 58700.0 nM 4.23
CHEMBL1917574 IC50 - -
CHEMBL1917572 IC50 - -
CHEMBL1917568 IC50 - -
CHEMBL1917567 IC50 - -
CHEMBL1917566 IC50 - -