Assay Detail
Binding
CHEMBL1921156
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Inhibition of human recombinant HDAC8 using Fluor de Lys as substrate
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.65 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1914708 | — | — | 1 | 7.77 |
| CHEMBL1914705 | — | — | 1 | 7.55 |
| CHEMBL1914703 | — | — | 1 | 7.12 |
| CHEMBL1914704 | — | — | 1 | 7.09 |
| CHEMBL1914706 | — | — | 1 | 6.83 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.36 |
| CHEMBL1914707 | — | — | 1 | 6.31 |
| CHEMBL1914702 | — | — | 1 | 6.19 |
| CHEMBL1914701 | — | — | 1 | 6.15 |
| CHEMBL585164 | — | — | 1 | 5.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1914708 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1914705 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL1914703 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL1914704 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL1914706 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL1914707 | — | IC50 | = | 487.0 | nM | 6.31 |
| CHEMBL1914702 | — | IC50 | = | 651.0 | nM | 6.19 |
| CHEMBL1914701 | — | IC50 | = | 707.0 | nM | 6.15 |
| CHEMBL585164 | — | IC50 | = | 7340.0 | nM | 5.13 |