Assay Detail
Binding
CHEMBL1921248
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of BODIPY-Bak conjugated peptide from GST-tagged human wild type Bcl-W expressed in Escherichia coli BL21 cells at 10 uM after 3 hrs by fluorescence polarization competition assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BL21 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Biochemical and pharmacological profiling of the pro-survival protein Bcl-xL.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.24 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1916194 | — | — | 1 | 7.68 |
| CHEMBL221854 | — | — | 1 | 7.31 |
| CHEMBL1916191 | — | — | 1 | 7.26 |
| CHEMBL1916193 | — | — | 1 | 7.23 |
| CHEMBL1916190 | — | — | 1 | 7.20 |
| CHEMBL1916192 | — | — | 1 | 6.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1916194 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL221854 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL1916191 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL1916193 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL1916190 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL1916192 | — | Ki | = | 170.0 | nM | 6.77 |