Assay Detail
Functional
CHEMBL1921324
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced actin polymerisation
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Challenges of drug discovery in novel target space. The discovery and evaluation of PF-3893787: a novel histamine H4 receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.59 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1915540 | ADRIFORANT | 2.0 | 1 | 8.89 |
| CHEMBL129198 | JNJ-7777120 | — | 1 | 8.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1915540 | ADRIFORANT | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL129198 | JNJ-7777120 | IC50 | = | 5.3 | nM | 8.28 |