Assay Detail
Binding
CHEMBL1921329
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-histamine from guinea pig H4R expressed in HEK293T cells
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Cell Type | HEK-293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Challenges of drug discovery in novel target space. The discovery and evaluation of PF-3893787: a novel histamine H4 receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 6.44 | 6.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1915540 | ADRIFORANT | 2.0 | 1 | 6.91 |
| CHEMBL129198 | JNJ-7777120 | — | 1 | 5.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1915540 | ADRIFORANT | Ki | = | 123.03 | nM | 6.91 |
| CHEMBL129198 | JNJ-7777120 | Ki | = | 1071.52 | nM | 5.97 |