Assay Detail
Binding
CHEMBL1921331
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-histamine from mouse H4R expressed in HEK293T cells
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | HEK-293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Challenges of drug discovery in novel target space. The discovery and evaluation of PF-3893787: a novel histamine H4 receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 8.05 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129198 | JNJ-7777120 | — | 1 | 8.41 |
| CHEMBL1915540 | ADRIFORANT | 2.0 | 1 | 7.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129198 | JNJ-7777120 | Ki | = | 3.89 | nM | 8.41 |
| CHEMBL1915540 | ADRIFORANT | Ki | = | 20.89 | nM | 7.68 |