Assay Detail
Binding
CHEMBL1924587
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]-MCH from MCHR1 after 2 hrs by beta scintillation counting
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Melanin-concentrating hormone receptor 1 (CHEMBL344) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a novel series of melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.13 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1922270 | — | — | 1 | 9.30 |
| CHEMBL1922269 | — | — | 1 | 9.05 |
| CHEMBL1922262 | — | — | 1 | 8.52 |
| CHEMBL1922271 | — | — | 1 | 8.36 |
| CHEMBL1922268 | — | — | 1 | 8.15 |
| CHEMBL1922265 | — | — | 1 | 7.40 |
| CHEMBL1922267 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1922270 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL1922269 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL1922262 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1922271 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL1922268 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1922265 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1922267 | — | IC50 | = | 750.0 | nM | 6.12 |