Assay Detail
Functional
CHEMBL1925476
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Antiproliferative activity against human PC3 cells after overnight incubation by CellTiter-Glo luminescence assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a potent, selective, and orally available class I phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) kinase inhibitor (GDC-0980) for the treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.54 | 6.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1922095 | — | — | 1 | 6.94 |
| CHEMBL1091978 | — | — | 1 | 6.66 |
| CHEMBL1922090 | — | — | 1 | 6.64 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 6.55 |
| CHEMBL1921986 | — | — | 1 | 6.53 |
| CHEMBL1083192 | — | — | 1 | 6.51 |
| CHEMBL1922094 | APITOLISIB | 2.0 | 1 | 6.51 |
| CHEMBL1922092 | — | — | 1 | 6.43 |
| CHEMBL1922093 | — | — | 1 | 6.34 |
| CHEMBL1922091 | — | — | 1 | 6.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1922095 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL1091978 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1922090 | — | IC50 | = | 228.0 | nM | 6.64 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL1921986 | — | IC50 | = | 295.0 | nM | 6.53 |
| CHEMBL1083192 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL1922094 | APITOLISIB | IC50 | = | 307.0 | nM | 6.51 |
| CHEMBL1922092 | — | IC50 | = | 367.0 | nM | 6.43 |
| CHEMBL1922093 | — | IC50 | = | 457.0 | nM | 6.34 |
| CHEMBL1922091 | — | IC50 | = | 556.0 | nM | 6.25 |