Assay Detail
Functional
CHEMBL1925792
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Cytotoxicity against doxorubicin-sensitive human MCF7 cells under oxic condition assessed as growth inhibition after 74 hrs by sulforhodamine B assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Hypoxia activated prodrugs of a 9-aza-anthrapyrazole derivative that has promising anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.53 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1417019 | MITOXANTRONE HYDROCHLORIDE | 4.0 | 1 | 7.00 |
| CHEMBL358035 | — | — | 1 | 6.05 |
| CHEMBL1923669 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1417019 | MITOXANTRONE HYDROCHLORIDE | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL358035 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL1923669 | — | IC50 | > | 25000.0 | nM | - |