Assay Detail
Functional
CHEMBL1929804
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MCF7 cells by alamar blue assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, biological evaluation and molecular modeling of 1,2,3-triazole analogs of combretastatin A-1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.49 | 5.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1927603 | — | — | 1 | 5.21 |
| CHEMBL1927605 | — | — | 1 | 4.57 |
| CHEMBL1927604 | — | — | 1 | 4.41 |
| CHEMBL1927607 | — | — | 1 | 4.33 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 4.31 |
| CHEMBL36255 | COMBRETASTATIN A-1 | 1.0 | 1 | 4.12 |
| CHEMBL1927601 | — | — | 1 | - |
| CHEMBL1927602 | — | — | 1 | - |
| CHEMBL1927606 | — | — | 1 | - |
| CHEMBL1927608 | — | — | 1 | - |
| CHEMBL1927609 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1927603 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL1927605 | — | IC50 | = | 26700.0 | nM | 4.57 |
| CHEMBL1927604 | — | IC50 | = | 38800.0 | nM | 4.41 |
| CHEMBL1927607 | — | IC50 | = | 46300.0 | nM | 4.33 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 48900.0 | nM | 4.31 |
| CHEMBL36255 | COMBRETASTATIN A-1 | IC50 | = | 75900.0 | nM | 4.12 |
| CHEMBL1927601 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1927602 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1927606 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1927608 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1927609 | — | IC50 | > | 100000.0 | nM | - |