Assay Detail
Functional
CHEMBL1929809
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of angiogenesis in endothelial cells assessed as inhibition of tube formation after 18 hrs by inverted microscopic analysis
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | Endothelial cell |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis, biological evaluation and molecular modeling of 1,2,3-triazole analogs of combretastatin A-1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.12 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.00 |
| CHEMBL1927604 | — | — | 1 | 6.52 |
| CHEMBL1927605 | — | — | 1 | 6.52 |
| CHEMBL36255 | COMBRETASTATIN A-1 | 1.0 | 1 | 5.50 |
| CHEMBL1927602 | — | — | 1 | 5.50 |
| CHEMBL1927606 | — | — | 1 | 5.47 |
| CHEMBL1927603 | — | — | 1 | 5.36 |
| CHEMBL1927601 | — | — | 1 | - |
| CHEMBL1927607 | — | — | 1 | - |
| CHEMBL1927608 | — | — | 1 | - |
| CHEMBL1927609 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1927604 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1927605 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL36255 | COMBRETASTATIN A-1 | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL1927602 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL1927606 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL1927603 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL1927601 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1927607 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1927608 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1927609 | — | IC50 | > | 10000.0 | nM | - |