Assay Detail
Binding
CHEMBL1929950
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDE7A assessed as hydrolysis of [3H]cAMP after 20 mins by scintillation proximity assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A (CHEMBL3012) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.68 | 5.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1927722 | — | — | 1 | 5.98 |
| CHEMBL1927721 | — | — | 1 | 5.77 |
| CHEMBL1927730 | — | — | 1 | 5.75 |
| CHEMBL1927729 | — | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1927722 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL1927721 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1927730 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL1927729 | — | IC50 | = | 6100.0 | nM | 5.21 |