Assay Detail
Binding
CHEMBL1930122
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Human immunodeficiency virus reverse transcriptase K103N mutant by SPA assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Design and synthesis of pyridone inhibitors of non-nucleoside reverse transcriptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 8.67 | 9.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL489586 | — | — | 1 | 9.41 |
| CHEMBL1928648 | — | — | 1 | 9.32 |
| CHEMBL1928645 | — | — | 1 | 8.82 |
| CHEMBL1928646 | — | — | 1 | 8.80 |
| CHEMBL1928647 | — | — | 1 | 8.68 |
| CHEMBL1928643 | — | — | 1 | 8.43 |
| CHEMBL1928644 | — | — | 1 | 7.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL489586 | — | Ki | = | 0.39 | nM | 9.41 |
| CHEMBL1928648 | — | Ki | = | 0.48 | nM | 9.32 |
| CHEMBL1928645 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL1928646 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL1928647 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL1928643 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL1928644 | — | Ki | = | 58.0 | nM | 7.24 |