Assay Detail
Functional
CHEMBL1930282
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of [14C]oleic acid oxidation in a human myotubes after 4 days by beta liquid scintillation counting
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis, molecular modeling studies and biological evaluation of fluorine substituted analogs of GW 501516.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 8.69 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38943 | GW501516 | 2.0 | 1 | 10.52 |
| CHEMBL1927473 | — | — | 1 | 8.43 |
| CHEMBL1927474 | — | — | 1 | 8.30 |
| CHEMBL1927475 | — | — | 1 | 7.50 |
| CHEMBL1927476 | — | — | 1 | - |
| CHEMBL121 | ROSIGLITAZONE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38943 | GW501516 | EC50 | = | 0.03 | nM | 10.52 |
| CHEMBL1927473 | — | EC50 | = | 3.7 | nM | 8.43 |
| CHEMBL1927474 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1927475 | — | EC50 | = | 31.4 | nM | 7.50 |
| CHEMBL1927476 | — | EC50 | - | — | - | |
| CHEMBL121 | ROSIGLITAZONE | EC50 | > | 1000.0 | nM | - |