Assay Detail
Binding
CHEMBL1930630
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 5-LOX assessed as decrease in oxygen concentration using arachidonic acid as substrate by polarigraphic method with Clark's oxygen electrode
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure based drug design, synthesis and evaluation of 4-(benzyloxy)-1-phenylbut-2-yn-1-ol derivatives as 5-lipoxygenase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.54 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL304818 | DOCEBENONE | 2.0 | 1 | 5.77 |
| CHEMBL1929096 | — | — | 1 | 5.10 |
| CHEMBL1929095 | — | — | 1 | 4.92 |
| CHEMBL1929093 | — | — | 1 | 4.39 |
| CHEMBL1929094 | — | — | 1 | 4.21 |
| CHEMBL1929089 | — | — | 1 | 4.16 |
| CHEMBL1929090 | — | — | 1 | 4.14 |
| CHEMBL1929091 | — | — | 1 | 4.10 |
| CHEMBL1929092 | — | — | 1 | 4.10 |
| CHEMBL1929086 | — | — | 1 | - |
| CHEMBL1929087 | — | — | 1 | - |
| CHEMBL1929088 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL304818 | DOCEBENONE | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1929096 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL1929095 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL1929093 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL1929094 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL1929089 | — | IC50 | = | 69000.0 | nM | 4.16 |
| CHEMBL1929090 | — | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL1929091 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL1929092 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL1929086 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1929087 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1929088 | — | IC50 | > | 100000.0 | nM | - |