Assay Detail
Functional
CHEMBL1930653
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of rat TAAR1 expressed in HEK293 cells assessed as accumulation of [3H]cAMP after 1 hr by competitive binding assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Trace amine-associated receptor 1 (CHEMBL3833) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Trace amine-associated receptor 1 is a stereoselective binding site for compounds in the amphetamine class.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.53 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1546 | HYDROXYAMPHETAMINE | 4.0 | 1 | 7.30 |
| CHEMBL19393 | LEVAMFETAMINE | 4.0 | 1 | 6.68 |
| CHEMBL612 | DEXTROAMPHETAMINE | 4.0 | 1 | 6.36 |
| CHEMBL43048 | MIDOMAFETAMINE | 3.0 | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1546 | HYDROXYAMPHETAMINE | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL19393 | LEVAMFETAMINE | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL612 | DEXTROAMPHETAMINE | EC50 | = | 440.0 | nM | 6.36 |
| CHEMBL43048 | MIDOMAFETAMINE | EC50 | = | 1700.0 | nM | 5.77 |