Assay Detail
Functional
CHEMBL1930658
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Activation of human TAAR1 expressed in Syrian hamster AV12-664 cells co-expressing GalphaS protein assessed as accumulation of cAMP after 30 mins using cAMP XS EA/CL as substrate by luminescence method in presence of RX821002 and alprenolol
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | AV12-664 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Trace amine-associated receptor 1 is a stereoselective binding site for compounds in the amphetamine class.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.14 | 6.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL610 | PHENETHYLAMINE | — | 1 | 6.97 |
| CHEMBL612 | DEXTROAMPHETAMINE | 4.0 | 1 | 6.00 |
| CHEMBL1182312 | — | — | 1 | 5.82 |
| CHEMBL19393 | LEVAMFETAMINE | 4.0 | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL610 | PHENETHYLAMINE | EC50 | = | 106.0 | nM | 6.97 |
| CHEMBL612 | DEXTROAMPHETAMINE | EC50 | = | 990.0 | nM | 6.00 |
| CHEMBL1182312 | — | EC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL19393 | LEVAMFETAMINE | EC50 | = | 1700.0 | nM | 5.77 |