Assay Detail
Functional
CHEMBL1930659
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Activation of human TAAR1 expressed in human HEK293T cells assessed as cAMP accumulation after 10 mins by BRET assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Trace amine-associated receptor 1 is a stereoselective binding site for compounds in the amphetamine class.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.44 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL612 | DEXTROAMPHETAMINE | 4.0 | 1 | 6.85 |
| CHEMBL19393 | LEVAMFETAMINE | 4.0 | 1 | 6.60 |
| CHEMBL195390 | — | — | 1 | 6.43 |
| CHEMBL1201201 | METHAMPHETAMINE | 4.0 | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL612 | DEXTROAMPHETAMINE | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL19393 | LEVAMFETAMINE | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL195390 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL1201201 | METHAMPHETAMINE | EC50 | = | 1300.0 | nM | 5.89 |