Assay Detail
Functional
CHEMBL1930671
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Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2mef infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by beta liquid scintillation counting method
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antimalarial evaluation of novel isocryptolepine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.72 | 7.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38827 | LUMEFANTRINE | 4.0 | 1 | 7.25 |
| CHEMBL1927688 | — | — | 1 | 7.07 |
| CHEMBL1927690 | — | — | 1 | 7.00 |
| CHEMBL1927689 | — | — | 1 | 6.95 |
| CHEMBL1927691 | — | — | 1 | 6.88 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.84 |
| CHEMBL1927687 | — | — | 1 | 6.74 |
| CHEMBL1927692 | — | — | 1 | 6.66 |
| CHEMBL1927685 | — | — | 1 | 6.50 |
| CHEMBL1927686 | — | — | 1 | 6.12 |
| CHEMBL502768 | ISOCRYPTOLEPINE HYDROCHLORIDE | — | 1 | 5.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38827 | LUMEFANTRINE | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL1927688 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL1927690 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1927689 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL1927691 | — | IC50 | = | 131.0 | nM | 6.88 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL1927687 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL1927692 | — | IC50 | = | 218.0 | nM | 6.66 |
| CHEMBL1927685 | — | IC50 | = | 316.0 | nM | 6.50 |
| CHEMBL1927686 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL502768 | ISOCRYPTOLEPINE HYDROCHLORIDE | IC50 | = | 1177.0 | nM | 5.93 |