Assay Detail
Binding
CHEMBL1930674
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]ditolylguanidine from sigma 2 receptor in rat liver membrane after 1.5 hrs by scintillation counting in presence of sigma 1 blocker (+)-pentazocine
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Electron-donating para-methoxy converts a benzamide-isoquinoline derivative into a highly Sigma-2 receptor selective ligand.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.10 | 7.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1927702 | — | — | 1 | 7.67 |
| CHEMBL1927694 | — | — | 1 | 7.57 |
| CHEMBL1927696 | — | — | 1 | 6.06 |
| CHEMBL1927698 | — | — | 1 | 5.85 |
| CHEMBL1927697 | — | — | 1 | 5.40 |
| CHEMBL1927699 | — | — | 1 | 5.28 |
| CHEMBL1927695 | — | — | 1 | 4.89 |
| CHEMBL1927700 | — | — | 1 | - |
| CHEMBL1927701 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1927702 | — | Ki | = | 21.26 | nM | 7.67 |
| CHEMBL1927694 | — | Ki | = | 26.78 | nM | 7.57 |
| CHEMBL1927696 | — | Ki | = | 866.7 | nM | 6.06 |
| CHEMBL1927698 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL1927697 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL1927699 | — | Ki | = | 5290.0 | nM | 5.28 |
| CHEMBL1927695 | — | Ki | = | 12930.0 | nM | 4.89 |
| CHEMBL1927700 | — | Ki | = | 152000.0 | nM | - |
| CHEMBL1927701 | — | Ki | > | 10000000.0 | nM | - |