Assay Detail
Binding
CHEMBL1930738
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Displacement of [3H]DTG from sigma 2 receptor in rat liver membranes
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities as σ₁ receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 6.81 | 7.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1929287 | — | — | 1 | 7.71 |
| CHEMBL1929280 | — | — | 1 | 7.55 |
| CHEMBL282433 | DITOLYLGUANIDINE | — | 1 | 7.46 |
| CHEMBL1929281 | — | — | 1 | 7.43 |
| CHEMBL1929279 | — | — | 1 | 7.42 |
| CHEMBL1929277 | — | — | 1 | 7.37 |
| CHEMBL1929278 | — | — | 1 | 7.20 |
| CHEMBL1929282 | — | — | 1 | 7.18 |
| CHEMBL1929286 | — | — | 1 | 6.96 |
| CHEMBL1929276 | — | — | 1 | 6.92 |
| CHEMBL1929284 | — | — | 1 | 6.71 |
| CHEMBL1929275 | — | — | 1 | 6.62 |
| CHEMBL128358 | — | — | 1 | 6.61 |
| CHEMBL1929430 | — | — | 1 | 6.38 |
| CHEMBL1929428 | — | — | 1 | 6.13 |
| CHEMBL1929283 | — | — | 1 | 5.74 |
| CHEMBL1929285 | — | — | 1 | 5.70 |
| CHEMBL1929429 | — | — | 1 | 5.48 |
| CHEMBL1929288 | — | — | 1 | - |
| CHEMBL1929289 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1929287 | — | Ki | = | 19.6 | nM | 7.71 |
| CHEMBL1929280 | — | Ki | = | 28.1 | nM | 7.55 |
| CHEMBL282433 | DITOLYLGUANIDINE | Ki | = | 34.3 | nM | 7.46 |
| CHEMBL1929281 | — | Ki | = | 37.5 | nM | 7.43 |
| CHEMBL1929279 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL1929277 | — | Ki | = | 42.3 | nM | 7.37 |
| CHEMBL1929278 | — | Ki | = | 63.6 | nM | 7.20 |
| CHEMBL1929282 | — | Ki | = | 65.9 | nM | 7.18 |
| CHEMBL1929286 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL1929276 | — | Ki | = | 119.0 | nM | 6.92 |
| CHEMBL1929284 | — | Ki | = | 194.0 | nM | 6.71 |
| CHEMBL1929275 | — | Ki | = | 242.0 | nM | 6.62 |
| CHEMBL128358 | — | Ki | = | 247.0 | nM | 6.61 |
| CHEMBL1929430 | — | Ki | = | 414.0 | nM | 6.38 |
| CHEMBL1929428 | — | Ki | = | 742.0 | nM | 6.13 |
| CHEMBL1929283 | — | Ki | = | 1810.0 | nM | 5.74 |
| CHEMBL1929285 | — | Ki | = | 1990.0 | nM | 5.70 |
| CHEMBL1929429 | — | Ki | = | 3330.0 | nM | 5.48 |
| CHEMBL1929288 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1929289 | — | Ki | > | 10000.0 | nM | - |