Assay Detail
Binding
CHEMBL1930744
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Inhibition of human dihydroorotate dehydrogenase
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dihydroorotate dehydrogenase (quinone), mitochondrial (CHEMBL1966) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Biaryl analogues of teriflunomide as potent DHODH inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.15 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1929450 | — | — | 1 | 7.58 |
| CHEMBL1929439 | — | — | 1 | 7.57 |
| CHEMBL1929453 | — | — | 1 | 7.51 |
| CHEMBL1929441 | — | — | 1 | 7.51 |
| CHEMBL1929437 | — | — | 1 | 7.51 |
| CHEMBL1929452 | — | — | 1 | 7.47 |
| CHEMBL1929442 | — | — | 1 | 7.40 |
| CHEMBL1929438 | — | — | 1 | 7.35 |
| CHEMBL1929443 | — | — | 1 | 7.31 |
| CHEMBL1929436 | — | — | 1 | 7.28 |
| CHEMBL1929448 | — | — | 1 | 7.23 |
| CHEMBL1929447 | — | — | 1 | 7.18 |
| CHEMBL1929451 | — | — | 1 | 7.18 |
| CHEMBL1929434 | — | — | 1 | 7.14 |
| CHEMBL1929449 | — | — | 1 | 7.12 |
| CHEMBL1929433 | — | — | 1 | 7.03 |
| CHEMBL1929445 | — | — | 1 | 7.01 |
| CHEMBL1929435 | — | — | 1 | 6.96 |
| CHEMBL1929446 | — | — | 1 | 6.86 |
| CHEMBL1929444 | — | — | 1 | 6.82 |
| CHEMBL1929432 | — | — | 1 | 6.82 |
| CHEMBL1929440 | — | — | 1 | 6.70 |
| CHEMBL973 | TERIFLUNOMIDE | 4.0 | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1929450 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL1929439 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL1929453 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL1929441 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL1929437 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL1929452 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL1929442 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1929438 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL1929443 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL1929436 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL1929448 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL1929447 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL1929451 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL1929434 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL1929449 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL1929433 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL1929445 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL1929435 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1929446 | — | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL1929444 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1929432 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1929440 | — | IC50 | = | 198.0 | nM | 6.70 |
| CHEMBL973 | TERIFLUNOMIDE | IC50 | = | 1083.0 | nM | 5.96 |