Assay Detail
Binding
CHEMBL1930753
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Inhibition of Escherichia coli PDHc-E1 expressed in Escherichia coli TB1 using sodium pyruvate as substrate after 3 mins by 2,6-DCIP reduction assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-based rational design of novel hit compounds for pyruvate dehydrogenase multienzyme complex E1 components from Escherichia coli.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.83 | 5.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1929454 | — | — | 1 | 5.16 |
| CHEMBL1929455 | — | — | 1 | 5.06 |
| CHEMBL1929456 | — | — | 1 | 4.82 |
| CHEMBL1929457 | — | — | 1 | 4.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1929454 | — | IC50 | = | 6880.0 | nM | 5.16 |
| CHEMBL1929455 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL1929456 | — | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL1929457 | — | IC50 | = | 55150.0 | nM | 4.26 |