Assay Detail
Functional
CHEMBL1930890
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Cytotoxicity against human KB cells after 72 hrs by sulforhodamine B and MTT assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel glycosylated diphyllin derivatives as topoisomerase II inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.73 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1929106 | — | — | 1 | 9.22 |
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 8.52 |
| CHEMBL1929104 | — | — | 1 | 8.52 |
| CHEMBL1929105 | — | — | 1 | 8.00 |
| CHEMBL1929100 | — | — | 1 | 7.82 |
| CHEMBL458904 | PATENTIFLORIN A | — | 1 | 7.03 |
| CHEMBL454803 | 4'-O-ACETYLPATENTIFLORIN B | — | 1 | 6.85 |
| CHEMBL1929098 | — | — | 1 | 6.39 |
| CHEMBL505932 | — | — | 1 | 6.36 |
| CHEMBL221190 | DIPHYLLIN | — | 1 | 6.11 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.07 |
| CHEMBL1929103 | — | — | 1 | 5.52 |
| CHEMBL1929102 | — | — | 1 | 5.39 |
| CHEMBL1929099 | — | — | 1 | 5.35 |
| CHEMBL1929101 | — | — | 1 | 5.31 |
| CHEMBL460047 | ACUTISSIMALIGNAN A | — | 1 | 5.16 |
| CHEMBL601587 | — | — | 1 | - |
| CHEMBL458905 | PATENTIFLORIN B | — | 1 | - |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1929106 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL90555 | VINCRISTINE | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1929104 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1929105 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1929100 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL458904 | PATENTIFLORIN A | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL454803 | 4'-O-ACETYLPATENTIFLORIN B | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL1929098 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL505932 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL221190 | DIPHYLLIN | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL1929103 | — | IC50 | = | 3050.0 | nM | 5.52 |
| CHEMBL1929102 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL1929099 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL1929101 | — | IC50 | = | 4890.0 | nM | 5.31 |
| CHEMBL460047 | ACUTISSIMALIGNAN A | IC50 | = | 6880.0 | nM | 5.16 |
| CHEMBL601587 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL458905 | PATENTIFLORIN B | IC50 | > | 10000.0 | nM | - |
| CHEMBL53463 | DOXORUBICIN | IC50 | - | — | - |