Assay Detail
Functional
CHEMBL1930892
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Cytotoxicity against human K562 cells after 72 hrs by sulforhodamine B and MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel glycosylated diphyllin derivatives as topoisomerase II inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.01 | 7.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1929104 | — | — | 1 | 7.36 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.37 |
| CHEMBL505932 | — | — | 1 | 6.09 |
| CHEMBL458904 | PATENTIFLORIN A | — | 1 | 5.84 |
| CHEMBL221190 | DIPHYLLIN | — | 1 | 5.78 |
| CHEMBL1929098 | — | — | 1 | 5.36 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.29 |
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1929104 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL505932 | — | IC50 | = | 808.0 | nM | 6.09 |
| CHEMBL458904 | PATENTIFLORIN A | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL221190 | DIPHYLLIN | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL1929098 | — | IC50 | = | 4402.0 | nM | 5.36 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 5160.0 | nM | 5.29 |
| CHEMBL90555 | VINCRISTINE | IC50 | - | — | - |