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Assay Detail

CHEMBL1931089

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against Human rhinovirus 1B infected in human HeLa cells assessed as inhibition of virus induced-plaque formation after 3 days by neutral red-based plaque reduction assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human rhinovirus 1B
Cell Type HeLa
Confidence 1 — Organism
Curated By Autocuration

Target

rhinovirus A1B (CHEMBL613713)
Type ORGANISM
Organism rhinovirus A1B

Publication

Design, synthesis and in vitro evaluation of novel chroman-4-one, chroman, and 2H-chromene derivatives as human rhinovirus capsid-binding inhibitors.
Conti C, Proietti Monaco L, Desideri N.
Bioorg Med Chem (2011) 19 : 7357 -7364
PubMed 22088306 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 5.61 7.58

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL29441 1 7.58
CHEMBL1927054 1 6.38
CHEMBL1926952 1 6.07
CHEMBL1926953 1 6.00
CHEMBL1926959 1 6.00
CHEMBL1927051 1 5.86
CHEMBL1926955 1 5.59
CHEMBL1927049 1 5.55
CHEMBL1926954 1 5.47
CHEMBL1927056 1 5.44
CHEMBL1926956 1 5.30
CHEMBL1927052 1 5.25
CHEMBL1926958 1 5.10
CHEMBL1926957 1 5.03
CHEMBL1927055 1 5.01
CHEMBL1927050 1 4.94
CHEMBL1927053 1 4.87

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL29441 IC50 = 26.0 nM 7.58
CHEMBL1927054 IC50 = 420.0 nM 6.38
CHEMBL1926952 IC50 = 850.0 nM 6.07
CHEMBL1926953 IC50 = 990.0 nM 6.00
CHEMBL1926959 IC50 = 990.0 nM 6.00
CHEMBL1927051 IC50 = 1390.0 nM 5.86
CHEMBL1926955 IC50 = 2540.0 nM 5.59
CHEMBL1927049 IC50 = 2790.0 nM 5.55
CHEMBL1926954 IC50 = 3350.0 nM 5.47
CHEMBL1927056 IC50 = 3610.0 nM 5.44
CHEMBL1926956 IC50 = 4980.0 nM 5.30
CHEMBL1927052 IC50 = 5570.0 nM 5.25
CHEMBL1926958 IC50 = 7890.0 nM 5.10
CHEMBL1926957 IC50 = 9300.0 nM 5.03
CHEMBL1927055 IC50 = 9730.0 nM 5.01
CHEMBL1927050 IC50 = 11490.0 nM 4.94
CHEMBL1927053 IC50 = 13590.0 nM 4.87