Assay Detail
Functional
CHEMBL1931091
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Antiviral activity against Human rhinovirus 14 infected in human HeLa cells assessed as inhibition of virus induced-plaque formation after 3 days by neutral red-based plaque reduction assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | rhinovirus B14 |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and in vitro evaluation of novel chroman-4-one, chroman, and 2H-chromene derivatives as human rhinovirus capsid-binding inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.82 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1926954 | — | — | 1 | 5.85 |
| CHEMBL1927051 | — | — | 1 | 5.22 |
| CHEMBL1927050 | — | — | 1 | 5.08 |
| CHEMBL1927053 | — | — | 1 | 4.96 |
| CHEMBL1926956 | — | — | 1 | 4.77 |
| CHEMBL1926957 | — | — | 1 | 4.70 |
| CHEMBL1926958 | — | — | 1 | 4.52 |
| CHEMBL1927052 | — | — | 1 | 4.44 |
| CHEMBL1927056 | — | — | 1 | 4.35 |
| CHEMBL1926959 | — | — | 1 | 4.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1926954 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL1927051 | — | IC50 | = | 6020.0 | nM | 5.22 |
| CHEMBL1927050 | — | IC50 | = | 8270.0 | nM | 5.08 |
| CHEMBL1927053 | — | IC50 | = | 11090.0 | nM | 4.96 |
| CHEMBL1926956 | — | IC50 | = | 17020.0 | nM | 4.77 |
| CHEMBL1926957 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL1926958 | — | IC50 | = | 30410.0 | nM | 4.52 |
| CHEMBL1927052 | — | IC50 | = | 36510.0 | nM | 4.44 |
| CHEMBL1927056 | — | IC50 | = | 45100.0 | nM | 4.35 |
| CHEMBL1926959 | — | IC50 | = | 47590.0 | nM | 4.32 |