Assay Detail
Binding
CHEMBL1931380
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Inhibition of Dengue virus NS2B-NS3 protease expressed in Escherichia coli BL21 lambda (DE3) using Abz-NleKRRS-3-(NO2)Y as substrate compound preincubated for 15 mins before substrate addition measured up to 15 mins by spectrofluorimetry
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Dengue virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Arylcyanoacrylamides as inhibitors of the Dengue and West Nile virus proteases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 4.23 | 4.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308048 | — | — | 1 | 4.45 |
| CHEMBL1927348 | — | — | 1 | 4.01 |
| CHEMBL1927522 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308048 | — | Ki | = | 35700.0 | nM | 4.45 |
| CHEMBL1927348 | — | Ki | = | 98100.0 | nM | 4.01 |
| CHEMBL1927522 | — | Ki | = | 184000.0 | nM | - |