Assay Detail
Functional
CHEMBL1931997
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Inhibition of TNFalpha-stimulated pro MMP9 production in human SRA 01/04 cells after 24 hrs by SDS-PAGE based gelatin zymography assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
B-Ring-modified and/or 5-demethylated nobiletin congeners: inhibitory activity against pro-MMP-9 production.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 4.69 | 5.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL225703 | — | — | 1 | 5.26 |
| CHEMBL438292 | — | — | 1 | 4.97 |
| CHEMBL74272 | — | — | 1 | 4.97 |
| CHEMBL479077 | — | — | 1 | 4.84 |
| CHEMBL1927280 | — | — | 1 | 4.81 |
| CHEMBL225704 | — | — | 1 | 4.79 |
| CHEMBL76447 | NOBILETIN | — | 1 | 4.77 |
| CHEMBL476121 | XANTHOMICROL | — | 1 | 4.65 |
| CHEMBL1927277 | — | — | 1 | 4.63 |
| CHEMBL1927278 | — | — | 1 | 4.62 |
| CHEMBL1927279 | — | — | 1 | 4.62 |
| CHEMBL76562 | — | — | 1 | 4.59 |
| CHEMBL495821 | — | — | 1 | 4.53 |
| CHEMBL73930 | TANGERETIN | — | 1 | 4.48 |
| CHEMBL75978 | 5-DEMETHYLNOBILETIN | — | 1 | 4.37 |
| CHEMBL1927276 | — | — | 1 | 4.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL225703 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL438292 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL74272 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL479077 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL1927280 | — | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL225704 | — | IC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL76447 | NOBILETIN | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL476121 | XANTHOMICROL | IC50 | = | 22300.0 | nM | 4.65 |
| CHEMBL1927277 | — | IC50 | = | 23500.0 | nM | 4.63 |
| CHEMBL1927278 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL1927279 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL76562 | — | IC50 | = | 25800.0 | nM | 4.59 |
| CHEMBL495821 | — | IC50 | = | 29600.0 | nM | 4.53 |
| CHEMBL73930 | TANGERETIN | IC50 | = | 33200.0 | nM | 4.48 |
| CHEMBL75978 | 5-DEMETHYLNOBILETIN | IC50 | = | 42400.0 | nM | 4.37 |
| CHEMBL1927276 | — | IC50 | = | 68000.0 | nM | 4.17 |