Assay Detail
Functional
CHEMBL1932149
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Antimalarial activity against multidrug-resistant Plasmodium falciparum K1 by microculture radioisotope technique
9
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Lanostane and hopane triterpenes from the entomopathogenic fungus Hypocrella sp. BCC 14524.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.33 | 8.96 |
| Activity | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL307261 | ARTENIMOL | 3.0 | 1 | 8.96 |
| CHEMBL535650 | MEFLOQUINE HYDROCHLORIDE | 4.0 | 1 | 7.40 |
| CHEMBL1928582 | — | — | 1 | 5.28 |
| CHEMBL1928579 | HYPOCRELLOL D | — | 1 | 5.10 |
| CHEMBL1928581 | — | — | 1 | 4.92 |
| CHEMBL1928577 | HYPOCRELLOL A | — | 1 | - |
| CHEMBL1928578 | HYPOCRELLOL B | — | 1 | - |
| CHEMBL1928576 | — | — | 1 | - |
| CHEMBL1928580 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL307261 | ARTENIMOL | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL535650 | MEFLOQUINE HYDROCHLORIDE | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1928582 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL1928579 | HYPOCRELLOL D | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL1928581 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL1928577 | HYPOCRELLOL A | Activity | - | — | - | |
| CHEMBL1928578 | HYPOCRELLOL B | Activity | - | — | - | |
| CHEMBL1928576 | — | Activity | - | — | - | |
| CHEMBL1928580 | — | Activity | - | — | - |