Assay Detail
Functional
CHEMBL1932399
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MCF7 cells after 4 days by propidium iodide staining-based fluorometric analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel inhibitors of epidermal growth factor receptor: (4-(Arylamino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)(1H-indol-2-yl)methanones and (1H-indol-2-yl)(4-(phenylamino)thieno[2,3-d]pyrimidin-6-yl)methanones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.95 | 5.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1928311 | — | — | 1 | 5.38 |
| CHEMBL554 | LAPATINIB | 4.0 | 1 | 5.32 |
| CHEMBL1928291 | — | — | 1 | 5.16 |
| CHEMBL1928312 | — | — | 1 | 4.95 |
| CHEMBL1928309 | — | — | 1 | 4.90 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1928311 | — | IC50 | = | 4220.0 | nM | 5.38 |
| CHEMBL554 | LAPATINIB | IC50 | = | 4830.0 | nM | 5.32 |
| CHEMBL1928291 | — | IC50 | = | 6960.0 | nM | 5.16 |
| CHEMBL1928312 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL1928309 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 100000.0 | nM | 4.00 |