Assay Detail
Binding
CHEMBL1936148
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Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Prostaglandin E2 receptor EP2 subtype (CHEMBL2488) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Discovery of a novel EP2/EP4 dual agonist with high subtype-selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 7.18 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1933724 | — | — | 1 | 8.52 |
| CHEMBL1933722 | — | — | 1 | 8.03 |
| CHEMBL1933728 | — | — | 1 | 7.89 |
| CHEMBL1933726 | — | — | 1 | 7.82 |
| CHEMBL1933725 | — | — | 1 | 7.72 |
| CHEMBL548 | DINOPROSTONE | 4.0 | 1 | 7.66 |
| CHEMBL1933727 | — | — | 1 | 7.38 |
| CHEMBL1933721 | — | — | 1 | 7.08 |
| CHEMBL1933719 | — | — | 1 | 6.90 |
| CHEMBL1933720 | — | — | 1 | 6.62 |
| CHEMBL1933723 | — | — | 1 | 6.50 |
| CHEMBL222715 | — | — | 1 | 6.47 |
| CHEMBL1933718 | — | — | 1 | 6.39 |
| CHEMBL223151 | — | — | 1 | 5.60 |
| CHEMBL42027 | — | — | 1 | - |
| CHEMBL1933717 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1933724 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL1933722 | — | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL1933728 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL1933726 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL1933725 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL548 | DINOPROSTONE | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL1933727 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL1933721 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL1933719 | — | Ki | = | 127.0 | nM | 6.90 |
| CHEMBL1933720 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL1933723 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL222715 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL1933718 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL223151 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL42027 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1933717 | — | Ki | > | 10000.0 | nM | - |