Assay Detail
Binding
CHEMBL1936154
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of electric eel AChE using acetylcholine as substrate measured every sec for 2 mins by Ellman's method
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
AChE inhibitor: a regio- and stereo-selective 1,3-dipolar cycloaddition for the synthesis of novel substituted 5,6-dimethoxy spiro[5.3']-oxindole-spiro-[6.3″]-2,3-dihydro-1H-inden-1″-one-7-(substituted aryl)-tetrahydro-1H-pyrrolo[1,2-c][1,3]thiazole.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.84 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1935151 | — | — | 1 | 6.96 |
| CHEMBL1678 | DONEPEZIL HYDROCHLORIDE | 4.0 | 1 | 6.92 |
| CHEMBL1935146 | — | — | 1 | 6.47 |
| CHEMBL1935141 | — | — | 1 | 6.32 |
| CHEMBL1935142 | — | — | 1 | 5.95 |
| CHEMBL1935152 | — | — | 1 | 5.94 |
| CHEMBL1935147 | — | — | 1 | 5.81 |
| CHEMBL1935153 | — | — | 1 | 5.68 |
| CHEMBL1935154 | — | — | 1 | 5.67 |
| CHEMBL1935148 | — | — | 1 | 5.65 |
| CHEMBL1935150 | — | — | 1 | 5.58 |
| CHEMBL1935155 | — | — | 1 | 5.50 |
| CHEMBL1935149 | — | — | 1 | 5.48 |
| CHEMBL1935145 | — | — | 1 | 5.24 |
| CHEMBL1935143 | — | — | 1 | 5.21 |
| CHEMBL1935144 | — | — | 1 | 5.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1935151 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1678 | DONEPEZIL HYDROCHLORIDE | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1935146 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL1935141 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL1935142 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL1935152 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL1935147 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL1935153 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL1935154 | — | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL1935148 | — | IC50 | = | 2240.0 | nM | 5.65 |
| CHEMBL1935150 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL1935155 | — | IC50 | = | 3160.0 | nM | 5.50 |
| CHEMBL1935149 | — | IC50 | = | 3280.0 | nM | 5.48 |
| CHEMBL1935145 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL1935143 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL1935144 | — | IC50 | = | 8320.0 | nM | 5.08 |